Expression of nm23-H1 and nm23-H2 protein in endometrial carcinoma
نویسندگان
چکیده
منابع مشابه
NM23-H1 and NM23-H2 messenger RNA abundance in human hepatocellular carcinoma.
nm23 was originally identified as an antimetastatic gene, the expression of which was inversely correlated with tumor metastatic potential in rodent model systems. Subsequently, two related human nm23 genes, nm23-H1 and nm23-H2, were identified. The relationship between expression of nm23-H1 and nm23-H2 in hepatocellular carcinoma specimens from 30 patients and metastatic potential was investig...
متن کاملIdentification of a second human nm23 gene, nm23-H2.
Reduced RNA and/or protein levels corresponding to the murine nm23-1 and human nm23-H1 complementary DNA clones have been correlated with high tumor metastatic potential in several rodent model systems and human breast carcinomas. We report the identification of a second human nm23 gene, designated nm23-H2. The pNM23-H2S complementary DNA clone predicted a Mr 17,000 protein 88% identical to nm2...
متن کاملnm23-H1 expression and loss of heterozygosity in colon adenocarcinoma.
BACKGROUND The discovery that genetic alterations in oncogenes and tumour suppressor genes accompany tumour formation in many human tumours has encouraged the search for genes that promote or suppress tumour spread and metastasis; nm23 is a promising candidate for a metastasis suppressing gene. AIMS To evaluate whether expression of nm23-H1 protein or loss of heterozygosity (LOH) of the nm23-...
متن کاملExpression and significance of heparanase and nm23-H1 in hepatocellular carcinoma.
AIM To explore the relation between heparanase (HPA) and nm23-H1 in hepatocellular carcinoma (HCC), and whether they could be used as valuable markers in predicting post-operative metastasis and recurrence of HCC. METHODS Reverse transcription-polymerase chain reaction and immunohistochemistry (S-P method) were used to measure the expressions of HPA mRNA and nm23-H1 protein in primary tumor t...
متن کاملExpression of nm23-H1 and COX-2 in thyroid papillary carcinoma and microcarcinoma
The expression of non-metastatic expressed/non-metastatic 23 nucleoside diphosphate kinase 1 (nm23-H1) and cyclooxygenase 2 (COX-2) proteins in thyroid carcinoma have been analysed in a number of previous studies, but this requires further study. The current study focused on the expression levels of nm23-H1 and COX-2 in 130 human thyroid papillary carcinoma (PTC) tissues. Of the 130 PTC tissues...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1995
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1995.531